IVF AFTER 40 YEARS

The success of IVF after 40 years depends on a number of factors that distinguish this category of patients. The most significant is the female factor.

Firstly, there is a direct inverse relationship between a woman’s age and the frequency of aneuploidy (the wrong number of chromosomes) in her ova, so if at 20 years only about 30% of oocytes have aneuploidy and 70% normal, then at 40-45 years old 70-80% oocytes have aneuploidy and 20-30% are normal, and after 45 more than 90-95% oocytes have aneuploidy.

Such a small number of cells with a normal set of chromosomes in women after 40 years has a significant negative impact on IVF success. A similar situation with age and the ovarian reserve. The older the woman, the fewer eggs can be received during the IVF cycle, so the fewer cells - the lower the chances. The ovarian reserve is rapidly reducing after 40. Therefore, the most rational option is to use the donor eggs, that solve both of these problems - the quantity and quality (frequency of aneuploidy) of the eggs, and obtain IVF results comparable to those of young healthy women. Naturally, the optimal decision can only be made jointly by the doctor and the patient, taking into account individual characteristics, among which, apart from the main ones, age and ovarian reserve (estimated on the basis of ultrasound and the level of AMH blood on days 2-3 of the month), the presence or absence of pregnancies and the parental status are also important, as well as the reason of infertility, the presence of concomitant gynecological pathology, the health of a partner, etc.

At the same time, modern technologies together with an appropriate attitude and willingness to overcome difficulties (often patients after 40 need for a longer term treatment), can achieve a positive result using their own eggs.

The Medical Center IGR has extensive experience in the successful treatment of such patients. In our clinic, we use the most modern treatment methods to improve the effectiveness of treatment, including ultramodern method - reconstruction of the patient’s oocytes using donor oocytes (increasing the number and improving the quality of eggs, preserving the genetic relation between patients and children).

In addition to the above-mentioned main factors, the general state of a woman’s health, the presence of serious diseases, concomitant gynecological pathology (endometriosis, fibromyoma, endometrial pathology, etc.), the partner’s health status, are also very important.